Julia Kubanek

Julia Kubanek

Julia Kubanek

Professor
Vice President of Interdisciplinary Research

Julia Kubanek serves as Georgia Tech’s Vice President for Interdisciplinary Research and is a professor in the School of Biological Sciences and the School of Chemistry and Biochemistry. In this role, she oversees and supports interdisciplinary activities at Georgia Tech including the Interdisciplinary Research Institutes (IRIs); the Pediatric Technology Center (PTC), the Novelis Innovation Hub; the Center for Advanced Brain Imaging (CABI); and the Global Center for Medical Innovation (GCMI). She also partners across the institute on developing and advancing new research initiatives based on student and faculty interests, expertise, and societal need.

Kubanek has held several previous leadership roles at Georgia Tech, including Associate Dean for Research in the College of Sciences and Associate Chair in the School of Biological Sciences. She joined the faculty at Georgia Tech in 2001. Her areas of research interest include chemical signaling among organisms (especially in aquatic systems), natural products chemistry, metabolomics, chemical biology, and drug discovery. She has authored approximately 100 research articles on marine plankton and coral reef chemical ecology, and on the discovery, mechanism of action, and biosynthesis of marine natural products. She was awarded the NSF CAREER Award in 2002, the Presidential Early Career Award for Scientists and Engineers (PECASE) in 2004, and was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2012. In 2016, she served as chair of the Gordon Research Conference in Marine Natural Products; since 2016, she has chaired the Scientific Advisory Board of the Max Planck Institute for Chemical Ecology. Kubanek received her B.Sc. in Chemistry from Queen’s University, Canada, in 1991 and her Ph.D. in at the University of British Columbia in 1998, and performed postdoctoral research at the University of California – San Diego and the University of North Carolina at Wilmington.

julia.kubanek@biosci.gatech.edu

404-894-8424

Office Location:
ES&T 2242

Lab Website

  • http://biosciences.gatech.edu/people/julia-kubanek
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    Research Focus Areas:
  • Drug Design, Development and Delivery
  • Health & Life Sciences
  • Systems Biology
  • Additional Research:
    All organisms use chemicals to assess their environment and to communicate with others. Chemical cues for defense, mating, habitat selection, and food tracking are crucial, widespread, and structurally and functionally diverse. Yet our knowledge of chemical signaling is patchy, especially in marine environments. In our research we ask, "How do marine organisms use chemicals to solve critical problems of competition, disease, predation, and reproduction?" Our group uses an integrated approach to understand how chemical cues function in ecological interactions, working from molecular to community levels. We also use ecological insights to guide discovery of novel pharmaceuticals and molecular probes. In collaboration with other scientists, our most significant scientific achievements to date are: 1) characterizing the unusual molecular structures of antimicrobial defenses that protect algae from pathogens and which show promise to treat human disease; 2) understanding that competition among single-celled algae (phytoplankton) is mediated by a complex interplay of chemical cues that affect harmful algal bloom dynamics; 3) unraveling the molecular modes of action of antimalarial natural products towards developing new treatments for drug-resistant infectious disease; 4) discovering that progesterone signaling and quorum sensing are key pathways in the alternating sexual and asexual reproductive strategy of microscopic invertebrate rotifers - animals whose evolutionary history was previously thought to preclude either cooperative behavior (quorum sensing) typically associated with bacteria and hormonal regulation via progesterone typically seen in vertebrates; 5) identifying a novel aversivechemoreception pathway in predatory fish thatresults inrapid recognition and rejectionofchemically defended foods, thereby protecting these foods (prey) from predators. Ongoing projects include: 1) Waterborne chemical cues in the marine plankton: a systems biology approach (including metabolomics); 2) Exploration, conservation, and development of marine biodiversity in Fiji and the Solomon Islands (including drug discovery, mechanisms of action, and chemical ecology); 3) The role of sensory environment and predator chemical signal properties in determining non-consumptive effect strength in cascading interactions on oyster reefs; 4) Regulation of red tide toxicity by chemical cues from marine zooplankton; 5) Chemoreception of prey chemical defenses on tropical coral reefs.

    IRI Connections:

    Amirali Aghazadeh

    Amirali Aghazadeh

    Amirali Aghazadeh

    Assistant Professor

    Amirali Aghazadeh is an Assistant Professor in the School of Electrical and Computer Engineering and also program faculty of Machine Learning, Bioinformatics, and Bioengineering Ph.D. programs. He has affiliations with the Institute for Data Engineering and Science (IDEAS) and Institute for Bioengineering and Biosciences. Before joining Georgia Tech, Aghazaeh was a postdoc at Stanford and UC Berkeley and completed his Ph.D. at Rice University. His research focuses on developing machine learning and deep learning solutions for protein and small molecular design and engineering.
     

    aaghazadeh3@gatech.edu

    713-257-5758

    Office Location:
    CODA S1209

    Profile Page

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    Research Focus Areas:
  • Algorithms & Optimizations
  • Big Data
  • Bioengineering
  • Bioinformatics
  • Biotechnology
  • Computational Genomics
  • Computational Materials Science
  • Diagnostics
  • Drug Design, Development and Delivery
  • Machine Learning
  • Systems Biology

  • IRI Connections:

    James Gumbart

    James Gumbart

    James Gumbart

    Associate Professor

    My lab is focused on understanding how proteins and other biological systems function at a molecular level. To probe these systems, we carry out molecular dynamics simulations, modeling biological behavior one atom at a time. The simulations serve as a "computational microscope" that permits glimpses into a cell's inner workings through the application of advanced software and high-powered supercomputers. We are particularly interested in how bacteria utilize unique pathways to synthesize proteins and insert them into both the inner and outer membranes, how they import nutrients across two membranes, and how their cell walls provide shape and mechanical strength.

    gumbart@physics.gatech.edu

    404-385-0797

    Office Location:
    Howey W202

    Website

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    University, College, and School/Department
    Research Focus Areas:
  • Molecular Evolution
  • Additional Research:
    Computational simulations of complex biophysical phenomena involving proteins and other biomolecules.

    IRI Connections:

    Melissa Kemp

    Melissa Kemp

    Melissa Kemp

    Professor
    Georgia Cancer Coalition Distinguished Cancer Scholar

    Melissa Lambeth Kemp received her B.S. in Nuclear Engineering from MIT and her Ph.D. in Bioengineering from University of Washington. Dr. Kemp joined the faculty at Georgia Tech in 2006 after completing postdoctoral training at MIT. Her expertise is in computational modeling of metabolism and signal transduction, as well as developing statistical modeling tools to examine network relationships in high-dimension datasets. One major aspect of her research program linking ROS – the byproducts of aerobic metabolism – to the fundamental way that cells interpret instructions from their environment, their neighbors, and their own genetic blueprint. Specific applications of her diverse work include systems modeling of transient phosphatase oxidation of kinase cascades, patient-specific differences in cytotoxicity to redox-cycled chemotherapeutics and radiation, and the coordination of oxidative metabolism with epithelial-to-mesenchymal transition. Her research program also includes a component of developing high-throughput screening methods for assaying cue-signal-response relationships in cells and analytical tools for single cell gene expression. 

    Dr. Kemp currently serves as the Research Director of the multi-site NSF Engineering Research Center “Cell Manufacturing Technologies”. In her former role as Associate Director of the NSF Science and Technology Center “Emergent Behavior of Integrated Cellular Systems”, she spearheaded the multi-site center’s computational activities by developing agent-based models of context-dependent cellular decisions to generate new hypotheses of intercellular communication in pluripotent stem cell differentiation and emergent patterning; this work continues currently in quantifying organizational principles and spatial relationships in iPSC-derived tissues from multi-omics data. Dr. Kemp’s career honors include a Whitaker Graduate Fellowship, Merck/CSBi postdoctoral fellowship, Georgia Cancer Coalition Distinguished Scholar, NIH New Innovator Award, and the CSB2 Prize for Innovative Measurement Methods from the Council for Systems Biology in Boston.

    melissa.kemp@bme.gatech.edu

    404-385-6341

    Office Location:
    EBB 3019

    Website

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    Research Focus Areas:
  • Cancer Biology
  • Chemical Biology
  • Systems Biology
  • Additional Research:
    Systems biology, computational modeling, redox metabolism and signal tranduction.The Kemp Lab is focused on understanding how metabolism influences the decisions that cells make. Aging, stem cell differentiation, cancer metastasis, and inflammation rely on progressive changes in metabolism resulting in increased levels of reactive oxygen species. Collectively, the accumulation of these molecules is known as cellular oxidation, and pathological levels are referred to as oxidative stress. Our lab develops systems biology tools for investigating how cellular oxidation influences cellular fate and interpretation of cues from the extracellular environment. We are interested in the collective behavior that arises during stem cell differentiation, immune cell responses, or drug treatments from metabolic diversity in individual cells. Because of the numerous biochemical reactions involved, we develop computational models and analytical approaches to understand how complex protein network properties are influenced by redox-sensitive proteins; these proteins typically have reactive thiol groups that are post-translationally regulated in the presence of reactive oxygen species to alter activity and/or function. Experimentally, we develop novel high-throughput single cell techniques for the detection and quantification of intracellular oxidation.

    IRI Connections:

    Kostas Konstantinidis

    Kostas Konstantinidis

    Kostas Konstantinidis

    Professor

    Dr. Kostas Konstantinidis joined the Georgia Institute of Technology as an Assistant Professor in November 2007. He received his BS in Agriculture Sciences from the Aristotle University of Thessaloniki (Greece) in 1999. He continued his studies at the Center for Microbial Ecology at Michigan State University (East Lansing, MI) under the supervision of Prof. James M. Tiedje, where he obtained a PhD in 2004. His PhD studies were fully supported by the Bouyoukos Fellowship program and were devoted in advancing our understanding of the ecology and physiology of soil bacteria through the comparative analysis of their whole-genome sequences. This research resulted in a NSF-funded project to advance the species definition for prokaryotes, which also fostered a short post-doc position at the Center for Microbial Ecology. He then moved to MIT and the laboratory of Prof. Edward DeLong to get trained on innovating metagenomic techniques. His work at MIT provided important new insights into the complexity and function of oceanic microbial communities as well as how life is adapting in the deep and cold Oceans. His research interests are at the interface of genomics and computational biology in the context of microbial ecology with the overarching goal to broaden understanding of the genetic and metabolic potential of the microbial world. Advancing our knowledge on these issues is essential for a better understanding of the microbes that power, by and large, the biogeochemical cycles that sustain life on Earth and cause or control important diseases in humans and animals. He is a member of the American Society for Microbiology (ASM), the International Society for Microbial Ecology (ISME) and the Association of Environmental Engineering and Science Professors (AEESP). Konstantinidis held the Carlton S. Wilder Junior Professorship for five years and subsequently received the Maulding Faculty Fellowship in the School of Civil and Environmental Engineering.

    kostas.konstantinidis@gatech.edu

    404-385-3628

    Office Location:
    ES&T 3224

    Website

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    Research Focus Areas:
  • Molecular Evolution
  • Systems Biology
  • Additional Research:
    Environmental microbiology and genomics Computational approaches for studying the ecology and evolution of microorganisms Development of genomic and proteomic techniques to investigate and quantify in-situ important microbial-mediated processes Population and single-cell genomics Assessing the extent and value of biodiversity within natural assemblages of Bacteria and Archaea Biotechnological applications of microbial functional diversity Environmental relevance of microbial diseases Our laboratory focuses on the smallest organisms on the planet, the bacteria and the archaea, which represent the largest reservoir of biodiversity on Earth, drive the life-sustaining biogeochemical cycles, and cause or control diseases in humans, animals, and plants. Our scientific interests are at the interface of microbial ecology with engineering and computational biology. The long-term goals of our research is to broaden understanding of the genetic and metabolic diversity of the microorganisms and to explore this biodiversity for biotechnological applications.

    IRI Connections:

    Christine Heitsch

    Christine Heitsch

    Christine Heitsch

    Professor

    Christine Heitsch is Professor of Mathematics at Georgia Tech, with courtesy appointments in Biological Sciences and Computational Science & Engineering as well as an affiliation with the Petit Institute for Bioengineering & Bioscience.

    She is also Director of the new Southeast Center for Mathematics and Biology (SCMB), an NSF-Simons MathBioSys Research Center, and finishing her tenure directing the GT Interdisciplinary Mathematics Preparation and Career Training (IMPACT) Postdoctoral Program.

    Heitsch's research interests lie at the interface between discrete mathematics and molecular biology, specifically combinatorial problems "as motivated by" and "with applications to" fundamental biomedical questions like RNA folding.

    Students interested in pursuing graduate studies in discrete mathematical biology can do so through a number of GT PhD programs including Bioinformatics or Quantitative Biosciences as well as Algorithms, Combinatorics, and Optimization (ACO), Computational Science & Engineering (CSE), and (of course) Mathematics.
     

    heitsch@math.gatech.edu

    404-894-4758

    Office Location:
    Skiles 211B

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  • University, College, and School/Department
    Research Focus Areas:
  • Systems Biology
  • Additional Research:
    Heitsch's research interests lie at the interface between discrete mathematics and molecular biology, specifically combinatorial problems "as motivated by" and "with applications to" fundamental biomedical questions like RNA folding.

    IRI Connections:

    Christopher Rozell

    Christopher Rozell

    Christopher Rozell

    Professor; School of Electrical and Computer Engineering
    Director; Sensory Information Processing Lab

    crozell@gatech.edu

    404.385.7671

    Office Location:
    Centergy One 5218

    SIPLab

  • ECE Profile Page
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    Research Focus Areas:
  • Artificial Intelligence (AI)
  • Neuroscience
  • Additional Research:

    Biological and computational vision Theoretical and computational neuroscience High-dimensional data analysis Distributed computing in novel architectures Applications in imaging, remote sensing, and biotechnology Dr. Rozell's research interests focus on the intersection of computational neuroscience and signal processing. One branch of this work aims to understand how neural systems organize and process sensory information, drawing on modern engineering ideas to develop improved data analysis tools and theoretical models. The other branch of this work uses recent insight into neural information processing to develop new and efficient approaches to difficult data analysis tasks.


    IRI Connections:

    Munmun De Choudhury

    Munmun De Choudhury

    Munmun De Choudhury

    Associate Professor; Director of Social Dynamics and Well-Being Laboratory; Co-Lead of Children's Healthcare of Atlanta Pediatric Technology Center at Georgia Tech's Patient-Centered Care Delivery

    Munmun De Choudhury is an Associate Professor at the School of Interactive Computing in Georgia Institute of Technology. Dr. De Choudhury is renowned for her groundbreaking contributions to the fields of computational social science, human-computer interaction, and digital mental health. Through fostering interdisciplinary collaborations across academia, industry, and public health sectors, Dr. De Choudhury and her collaborators have contributed significantly to advancing the development of computational techniques for early detection and intervention in mental health, as well as in unpacking how social media use benefits or harms mental well-being. De Choudhury's contributions have been recognized worldwide, with significant scholarly impact evidenced by numerous awards like induction into the SIGCHI Academy and the 2023 SIGCHI Societal Impact Award. Beyond her academic achievements, Dr. De Choudhury is a proactive community leader, a persistent contributor to policy-framing and advocacy initiatives, and is frequently sought for expert advice to governments, and national and international media.

     

    munmund@gatech.edu

    4043858603

    http://www.munmund.net/biography.html

    Research Focus Areas:
  • Big Data
  • Bioinformatics
  • Diagnostics
  • Health & Life Sciences
  • Healthcare
  • Machine Learning
  • Public Health
  • Social & Environmental Impacts

  • IRI Connections:

    Eva Dyer

    Eva Dyer

    Eva Dyer

    Assistant Professor

    Dyer’s research interests lie at the intersection of machine learning, optimization, and neuroscience. Her lab develops computational methods for discovering principles that govern the organization and structure of the brain, as well as methods for integrating multi-modal datasets to reveal the link between neural structure and function.

    evadyer@gatech.edu

    404-894-4738

    Office Location:
    UAW 3108

    Website

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    Research Focus Areas:
  • AI
  • Neuroscience
  • Additional Research:

    Eva Dyer’s research combines machine learning and neuroscience to understand the brain, its function, and how neural circuits are shaped by disease. Her lab, the Neural Data Science (NerDS) Lab, develops new tools and frameworks for interpreting complex neuroscience datasets and building machine intelligence architectures inspired by the brain. Through a synergistic combination of methods and insights from both fields, Dr. Dyer aims to advance the understanding of neural computation and develop new abstractions of biological organization and function that can be used to create more flexible AI systems.


    IRI Connections:

    Christopher Wiese

    Christopher Wiese

    Christopher Wiese

    Assistant Professor

    My research focuses on three major areas: (a) understanding and improving worker well-being, (b) temporal dynamics in team contexts, and (c) research methods. Collectively, my research seeks to improve our understanding of optimal human functioning more generally, across time, and within specific contexts (e.g., organizational, teams).

    ChrisWiese@gatech.edu

    Website

    University, College, and School/Department

    IRI Connections: