Marvin Whiteley

Marvin Whiteley

Marvin Whiteley

Professor
Bennie H. & Nelson D. Abell Chair in Molecular and Cellular Biology
Georgia Research Alliance Eminent Scholar
Co-Director, Emory-Children's CF Center (CF@LANTA)

Dr. Whiteley received his B.S. degree in Zoology in 1995 from the University of Texas at Austin and his Ph.D. in Microbiology from the University of Iowa in 2001. His doctoral research involved quorum sensing and biofilm formation in the bacterium Pseudomonas aeruginosa. Following a Postdoctoral Fellowship at Stanford University in 2002, Dr. Whiteley accepted a position as an assistant professor at the University of Oklahoma/Oklahoma Health Sciences Center. In 2006, Dr. Whiteley moved to the University of Texas at Austin where he was promoted to Professor of Molecular Biosciences and Director of the LaMontagne Center for Infectious Disease. In 2017, he accepted the Bennie H. & Nelson D. Abell Chair and Georgia Research Alliance Eminent Scholar in Molecular and Cellular Biology at Georgia Institute of Technology. He also serves as Associate Director of the CF-Air Center at Emory Medical School. Dr. Whiteley has garnered numerous awards for his work including the Merck Irving S. Sigal Memorial Award for national research excellence, the Burroughs Wellcome Investigators in Pathogenesis of Infectious Disease award, recognition as a Kavli fellow of the National Academy of Sciences, the Dean’s teaching excellence award from UT-Austin, and election to the American Academy of Microbiology.

marvin.whiteley@biosci.gatech.edu

404-385-5697

Office Location:
Petit Biotechnology Building, Office 1314

Website

  • http://biosci.gatech.edu/people/marvin-whiteley
  • Google Scholar

    Research Focus Areas:
  • Drug Design, Development and Delivery
  • Systems Biology
  • Additional Research:
    In the Whiteley Lab, we are interested in the social lives of bacteria. Currently, we are utilizing new technologies combined with classical genetic techniques to address questions about microbial physiology, ecology, virulence, and evolution. In particular, we are working on tackling the following questions: 1. How do bacteria communicate? 2. How do polymicrobial interactions impact physiology and virulence? 3. What is the role of spatial structure in bacterial infections? 4. How does the host environment impact microbial physiology?

    IRI Connections:

    Timothy Cope

    Timothy Cope

    Timothy Cope

    Professor

    My research interests center on control of movement by sensorimotor integration in the mammalian spinal cord. Using predominantly electrophysiological methods applied in vivo, we study neural signaling by spinal motoneurons, somatosensory neurons, and their central synapses. Our primary analyses include electrical properties, synaptic function, and firing behavior of single neurons. We are actively examining how these neurons and synapses respond soon and long after peripheral nerve injury and regeneration. Our recent findings demonstrate that successful regeneration of damaged sensory axons does not prevent complex reorganization of their synaptic connections made within the spinal cord. In separate studies, we are examining novel mechanisms of sensory encoding and their impairment which recently discovered in rodents treated with anti-cancer drugs. Both nerve regeneration and chemotherapy projects are driven by the long-term goal of accurately identifying the neural mechanisms behind movement disorders. We also continue to explore fundamental operations of the normal adult nervous system. Our most recent studies focus on synaptic modulation of motoneuron firing and on interspecies comparisons of spinal circuits.

    tim.cope@gatech.edu

    404-385-4293

    Office Location:
    555 14th Street NW Room 1425

    Website

  • https://biosci.gatech.edu/people/timothy-cope
  • Google Scholar

    Research Focus Areas:
  • Neuroscience
  • Regenerative Medicine

  • IRI Connections:

    Yury Chernoff

    Yury Chernoff

    Yury Chernoff

    Professor
    Director, Center for Nanobiology of the Macromolecular Assembly Disorders (NanoMAD)

    Yury O. Chernoff is a professor in the School of Biology and Institute for Bioengineering and Bioscience and Editor-in-Chief of the scientific journal Prion. He received his undergraduate and graduate training and Ph.D. degree in biology from St. Petersburg (then Leningrad) State University (Russia) and performed postdoctoral research at Okayama University (Japan) and University of Illinois at Chicago. 

    Major topics of Dr. Chernoff’s research include yeast models for the protein aggregation disorders with an emphasis on the cellular control of protein aggregation and prion propagation, sequence-specificity of amyloid formation, and evolution of prion properties. 

    Dr. Chernoff’s work provided the first experimental evidence for the chaperone role in prion phenomena.

    yury.chernoff@biology.gatech.edu

    404-894-1157

    Office Location:
    EBB 5016

    Website

  • http://www.biology.gatech.edu/people/yury-chernoff
  • Google Scholar

    Research Focus Areas:
  • Molecular Evolution
  • Additional Research:
    Yeast genetics and molecular biology, chaperones and protein misfolding, amyloid and prion diseases, epigenetics and protein-based inheritance. Mylaboratory employsyeast models to studyprionsandamyloids.Prionswere initially identified as proteins in an unusual conformation that cause infectiousneurodegenerativediseases, such as "mad cow" disease,kuruorCreutzfeldt-Jakobdisease. Infection depends on theprion'sability to convert anon-prionprotein, encoded by the same host maintenance gene, into theprionconformation.Prionsform ordered cross-beta fibrous aggregates, termed amyloids. A variety of human diseases, includingAlzheimer'sdisease, are associated with amyloids and possess at least someprionproperties. Someamyloidshave positive biological functions. Manyproteins can formamyloidsin specific conditions. It is thought thatamyloidrepresents one of the ancient types of the protein fold. Some yeastnon-Mendelianheritable elements are based on aprionmechanism. This shows that heritable information can be coded in protein structures, in addition to information coded in DNA sequence. Therefore,prionsprovide a basis for the protein-based inheritance in yeast (and possibly in other organisms). Major topics of research in my lab include cellular control of prion formation and propagation (with a specific emphasis on the role of chaperone proteins), and development of the yeast models forstudying mammalian and humanamyloids, involved in diseases.Our research has demonstrated thatprionscan be induced by transient protein overproduction and discovered the crucial role of chaperones inprionpropagation, shown evolutionary conservation ofprion-formingproperties, established a yeast system for studying species-specificity ofpriontransmission,and uncovered links between prions,cytoskeletalnetworks and protein quality control pathways.

    IRI Connections:

    Alfred H. Merrill

    Alfred H. Merrill

    Alfred Merrill

    Professor
    Smithgall Chair in Molecular Cell Biology

    Throughout my career, my laboratory has studied sphingolipids, a category of lipids that are important in cell structure, signal transduction and cell-cell communication. For more information about what we found, please refer to the Google Scholar or PubMed links below. 

    As an Emeritus Professor, I am working on a project that has interested me for a long time--the fact that the active agent in the venom of the brown recluse spider is a sphingomyelinase D that produces a novel product, ceramide 1,3-cyclic phosphate. This activity has also been found in other spiders, bacteria and fungi. With the help of collaborators, I hope to learn more about the organisms that produce and degrade this novel sphingolipid, and possibly find ways to reduce the injury caused by the enzyme when humans encounter it in the environment.

    al.merrill@biology.gatech.edu

    404-385-2842

    Office Location:
    Petit Biotechnology Building, Office 3309

  • http://www.biology.gatech.edu/people/al-merrill
  • Google Scholar

    Research Focus Areas:
  • Cancer Biology
  • Drug Design, Development and Delivery
  • Molecular Evolution
  • Additional Research:
    My laboratory studies a category of lipids, termed sphingolipids, that are important in cell structure, cell-cell communication and signal transduction. This research concerns both complex sphingolipids (sphingomyelins and glycosphingolipids) and the lipid backbones (ceramide, sphingosine, sphingosine 1-phosphate and others) that regulate diverse cell behaviors, including growth, differentiation, autophagy and programmed cell death. The major tool that we use to identify and quantify these compounds is tandem mass spectrometry, which we employ in combination with liquid chromatography for "lipidomic" analysis and in other mass spectrometry platforms (e.g., MALDI) for "tissue imaging" mass spectrometry. To assist interpretation of the mass spectrometry results, and to predict where interesting changes in sphingolipid metabolism might occur, we use tools for visualization of gene expression data in a pathway context (e.g., a "SphingoMAP"). These methods are used to characterize how sphingolipids are made, act, and turned over under both normal conditions and diseases where sphingolipids are involved, such as cancer, and where disruption of these pathways can cause disease, as occurs upon consumption of fumonisins. Since sphingolipids are also components of food, we determine how dietary sphingolipids are digested and taken up, and become part of the body's "sphingolipidome."

    IRI Connections:

    Lewis Wheaton

    Lewis Wheaton

    Lewis Wheaton

    Associate Professor
    Adjunct Associate Professor, Department of Rehabilitation Medicine, Emory University

    Dr. Lewis A. Wheaton received his Ph.D. in Neuroscience and Cognitive Sciences from the University of Maryland, College Park in 2005. He was a fellow at the National Institutes of Health (Medical Neurology Branch, 2001-2005) studying neural function and recovery of motor control after stroke. In mid-2005 he was awarded a post-doctoral fellowship at the Baltimore Veterans Affairs Medical Center (Maryland) where he performed neuroscience research in aging and stroke motor control in Veterans.

    In 2008, Dr. Wheaton joined the School of Applied Physiology at Georgia Tech as an Assistant Professor. He became tenured in 2014 and is currently an Associate Professor in Biological Sciences. Dr. Wheaton is the Director of the Cognitive Motor Control Laboratory at Georgia Tech, engaged in over $1 million in state and federal research funding focused on understanding aspects of human motor control rehabilitation in aging, stroke and amputation. His lab has employed numerous high school, undergraduate, graduate, and post-doctoral fellows. He is the course director for 4 courses in the School of Biological Sciences (Human Neuroimaging, Movement Disorders, Human Neuroanatomy, and the History of Neuroscience). He has Chaired/Co-Chaired 3 international conferences focused on motor control research and clinical outcomes, obtaining funding by federal and private sources. His research has yielded several manuscript publications in the field of motor control neuroscience, several focused expert reviews, and numerous conference presentations both in the US and abroad.

    Dr. Wheaton is also an adjunct Associate Professor in the Department of Rehabilitation at Emory School of Medicine and a Member of the Children’s Center for Neurosciences Research at the Emory Children’s Pediatric Research Center.

    Dr. Wheaton earned a BS (Biology) degree at Radford University (VA). He is an active parent volunteer at his children's schools and in the local community.

    lewis.wheaton@ap.gatech.edu

    404-385-2339

    Office Location:
    555 14th Street 1309E

    Website

  • http://biosci.gatech.edu/people/Lewis-Wheaton
  • News Story about C-PIES Appointment
  • Google Scholar

    Research Focus Areas:
  • Neuroscience
  • Additional Research:
    The Cognitive Motor Control Laboratory seeks to understand neurophysiology guiding skillful human-object interactions in upper extremity motor control. We use neuroimaging to identify anatomical and physiological circuits in humans that guide successful skilled behavior. Our clinical studies consider neural systems that can suffer injury or dysfunction related to deficits in skillful motor control, and how to utilize surrogate neural circuits in restorative motor therapies in stroke and upper limb amputation.

    IRI Connections:

    Boris Prilutsky

    Boris Prilutsky

    Boris Prilutsky

    Professor

    The research focus of Boris Prilutsky's laboratory is Neural Control and Biomechanics of Movement. They study how the nervous system controls hundreds of muscles and kinematic degrees of freedom of the body to produce purposeful motor behaviors and how the neural control of motor behaviors is affected by neural and musculoskeletal injuries.

    boris.prilutsky@biosci.gatech.edu

    404-894-7659

    Office Location:
    MSPO Program 1309D

    Website

  • http://biosci.gatech.edu/people/boris-Prilutsky
  • Google Scholar

    Research Focus Areas:
  • Molecular, Cellular and Tissue Biomechanics
  • Neuroscience
  • Regenerative Medicine
  • Systems Biology
  • Additional Research:
    The major research focus of my research is on biomechanics and motor control of locomotion and reaching movements in normal as well as in neurological and musculoskeletal pathological conditions. In particular, we study the mechanisms of sensorimotor adaptation to novel motor task requirements caused by visual impairament, peripheral nerve or spinal cord injury, and amputation. We also investigate how motor practice and sensory information affect selections of adaptive motor strategies.

    IRI Connections:

    William Ratcliff

    William Ratcliff

    William Ratcliff

    Assistant Professor

    I am an evolutionary biologist broadly interested in the evolution of complex life. My Ph.D. training focused on the evolutionary stability of cooperation in the legume-rhizorium symbiosis. Here I developed new experimental methods to study how among-organism genetic conflict arises and can be mitigated. A similar evolutionary tension lies at the heart of all key events in the origin of complex life, termed the ‘Major Transitions in Evolution’: namely, how do new organisms arise and evolve to be more complex without succumbing to within-organism conflict? Studying the early evolution of multicellular organisms has been particularly difficult because these transitions occurred deep in the past, and transitional forms have largely lost to extinction. As a postdoc, I circumvented this constraint by creating a new approach to study the evolution of multicellularity: we evolved it de novo. Since founding my own research group at Georgia Tech in 2014, I have combined this approach with mathematical modeling and synthetic biology to examine how simple clumps of cells evolve into multicellular organisms. Our research has shown how classical constraints in the origin of multicellularity — e.g., the origin of life cycles, multicellular development, cellular differentiation, and cellular interdependence — can be solved by Darwinian evolution. At home, I raise two kids on a hobby farm (really just a big garden) with bees, chickens, rabbits, goats, a dog, and lots of edible plants.

    william.ratcliff@biology.gatech.edu

    404-894-8906

    Office Location:
    ES&T 2240

    Website

  • http://snowflakeyeastlab.com/
  • Google Scholar

    Additional Research:
    Major transitions in evolution (mainly multicellularity). Spatial dynamics of microbial social interactions. Bet hedging. Life cycle evolution. Origin of multicellular development. The transition to multicellularity was critical for the evolution of of large, complex organisms. However, little is known about how early multicellular organisms arise from unicellular ancestors, or how these relatively simple clusters of cells evolve greater complexity. We address both of these issues using experimental evolution, creating new multicellular life in a test tube. Using these model systems (and a good bit of mathematical / computational modeling), my lab explores the origin of multicellular development, cellular division of labor, and mechanisms to prevent cell-level evolution from eroding multicellular complexity. Major transitions in evolution (e.g. multicellularity) are a special case of a more general phenomenon: social evolution. Through collaborations with Brian Hammer (GT Biology), Peter Yunker (GT Physics), and Joshua Weitz (GT Biology), our group examines the spatial dynamics of microbial ecology and evolution.

    IRI Connections:

    Michael Goodisman

    Michael Goodisman

    Michael Goodisman

    Professor
    Associate Chair for Undergraduate Education

    Michael Goodisman is interested in understanding how evolutionary processes affect social systems and how sociality, in turn, affects the course of evolution. His research explores the molecular basis underlying sociality, the nature of selection in social systems, the breeding biology of social animals, the process of self-organization in social groups, and the course of development in social species. His teaching interests are centered on the importance of behavior, genetics, and ethics in biological systems. Goodisman also works to improve and advance undergraduate education.

    michael.goodisman@biology.gatech.edu

    404-385-6311

    Office Location:
    Cherry Emerson A124

    Website

  • http://www.biology.gatech.edu/people/michael-goodisman
  • Google Scholar

    Research Focus Areas:
  • Molecular Evolution
  • Neuroscience
  • Additional Research:
    The evolution of sociality represented one of the major transition points in biological history. I am interested in understanding how evolutionary processes affect social systems and how sociality, in turn, affects the course of evolution. My research focuses on the molecular basis underlying sociality, the nature of selection in social systems, the breeding biology of social animals, the process of self-organization in social groups, and the course of development in social species.

    IRI Connections:

    Roger Wartell

    Roger Wartell

    Roger Wartell

    Professor Emeritus

    Roger Wartell received his B.S. degree in Physics from Stevens Institute of Technology in 1966. In 1971, he received his Ph.D. in Physics from the University of Rochester where he worked in the group of Elliot Montroll on the DNA helix-coil transition. From 1971-1973 he was a NIH postdoctoral fellow in the laboratory of Robert Wells at the University of Wisconsin-Madison. He was a Visiting Professor at the University of Wisconsin-Madison in 1978-79, and Visiting Scholar at National Institutes of Health-Bethesda from 1987-88. 

    Wartell joined the faculty at Georgia Tech in 1974. Roger received a NIH Career Development Award in 1979 and served as Associate Chair in School of Physics from 1987-88, and Chair of the School of Biology from 1990-2004. He is a member of the NASA Astrobiology Institute at Georgia Tech. His current research is focused on protein-RNA interactions relating to sRNA regulation in bacteria, and the assembly and reactions of small RNAs in ice.


    404-894-8421

    Office Location:
    Petit Biotechnology Building, Office 1307

  • http://biosciences.gatech.edu/people/roger-wartell
  • Google Scholar

    Research Focus Areas:
  • Molecular Evolution
  • Additional Research:
    Current research is directed at understanding the origin and evolution of RNA assemblies and activities that gave rise to RNA-based genetic and metabolic systems, and the interaction of a bacterial RNA-binding protein Hfq that is crucial for the regulation of gene expression by short regulatory RNAs. The first research area is examining the assembly and activities of RNAunder plausible early earth conditions ( e.g. anoxic environment, freeze-thaw cycles of aqueous solutions). We have shown that Fe2+can replace Mg2+and enhance ribozyme function under anoxic conditions. Fe2+was abundant on early earth and may have enhanced RNA activities in an anoxic environments. Freeze-thaw cycles can also promote RNA assembly under conditions where degradation is minimized. The second area of research is investigating the mechanism of the Hfq protein. Hfq is a bacterial RNA-binding protein that facilitates the hybridization of short non-coding regulatory RNAs (sRNA)to their target regions on specific mRNAs. sRNAs are important elements in the regulation of gene expression for bacteria.Hfq is highly conserved among bacterial phyla and has been shown to be a virulence factor in several bacterial species. The interactions of wild type and mutant Hfq proteins with various RNAs are examined using biochemical/ biophysical methods such as the electrophoresis mobility shift assay, fluorescence spectroscopy, and mass spectrometry.

    IRI Connections:

    T. Richard Nichols

    T. Richard Nichols

    T. Richard Nichols

    Professor

    T. Richard Nichols received the B.S. degree in biology from Brown University, Providence, RI, USA, in 1969, and the Ph.D. degree in physiology from Harvard University, Cambridge, MA, USA, in 1974. He is currently a Professor in the School of Biological Sciences at the Georgia Institute of Technology.,He is currently a Professor in the School of Biological Sciences at the Georgia Institute of Technology, Atlanta, GA, USA.

    trn@gatech.edu

    404-894-3986

    Office Location:
    555 14th Street NW Room 1352

  • http://biosci.gatech.edu/people/richard-nichols
  • Google Scholar

    Research Focus Areas:
  • Molecular, Cellular and Tissue Biomechanics
  • Neuroscience
  • Additional Research:
    The work in this laboratory is focused on mechanisms underlying motor coordination in mammalian systems. These mechanisms are to be found in the structure and dynamic properties of the musculoskeletal system as well as in the organization of neuronal circuits in the central nervous system. Our work concerns the interactions between the musculoskeletal system and spinal cord that give rise to normal and abnormal movement and posture, and in the manner in which central pattern-generating networks are modified for specific motor tasks. Our studies have applications in several movement disorders, including spinal cord injury. The experimental approaches span a number of levels, from mechanical studies of isolated muscle cells to kinematic measurements of natural behavior in quadrupeds.

    IRI Connections: