C. Ross Ethier

C. Ross Ethier

C. Ross Ethier

Professor
Georgia Research Alliance Lawrence L. Gellerstedt, Jr. Eminent Scholar in Bioengineering

Prof. Ethier was originally trained as a mechanical engineer, receiving his Ph.D. from MIT in 1986 working in the lab of Roger D. Kamm. He then joined the University of Toronto, where he was a Professor of Bioengineering, Mechanical Engineering and Ophthalmology, and latterly the Director of the Institute of Biomaterials and Biomedical Engineering. Prior to joining Georgia Tech/Emory, Professor Ethier was the Head of the Department of Bioengineering at Imperial College, London from 2007-12. 

His research is in the biomechanics of cells and whole organs. His specific research topics include glaucoma (biomechanics of aqueous humour drainage in the normal and glaucomatous eye, and the mechanical and cellular response of optic nerve tissues to intraocular pressure), study of hemodynamic basis of arterial disease.

ross.ethier@bme.gatech.edu

404-385-0100

Office Location:
Petit Biotechnology Building, Office 2306

Website

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    Research Focus Areas:
  • Molecular, Cellular and Tissue Biomechanics
  • Neuroscience
  • Regenerative Medicine
  • Additional Research:
    "Biomechanics and mechanobiology, glaucoma, osteoarthritis, regenerative medicine, intraocular pressure control, optic nerve head biomechanics. We work at the boundaries between mechanics, cell biology and physiology to better understand the role of mechanics in disease, to repair diseased tissues, and to prevent mechanically-triggered damage to tissues and organs. Glaucoma is the second most common cause of blindness. We carry out a range of studies to understand and treat this disease. For example, we are developing a new, mechanically-based, strategy to protect fragile neural cells that, if successful, will prevent blindness. We are developing protocols for stem-cell based control of intraocular pressure. We study the mechanobiology and biomechanics of neurons and glial cells in the optic nerve head. We also study VIIP, a major ocular health concern in astronauts. Osteoarthritis is the most common cause of joint pain. We are developing paradigms based on magneto-mechanical stimulation to promote the differentiation and (appropriate) proliferation of mesenchymal stem cells."

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    Susan Margulies

    Susan Margulies

    Susan Margulies

    Professor
    National Science Foundation Engineering Directorate

    Dr. Susan S. Margulies leads the U.S. National Science Foundation’s Directorate for Engineering in its mission to transform our world for a better tomorrow by driving discovery, inspiring innovation, enriching education, and accelerating access. With an annual budget of nearly $800 million, the NSF’s Engineering Directorate provides over 40 percent of federal funding for fundamental research in engineering at academic institutions, and it distributes more than 1500 awards supporting research and education each year. Projects funded by the Engineering Directorate span frontier research to generate new knowledge, problem-driven research to identify new solutions to societal challenges, and application-driven research to translate discoveries to uses that benefit society.

    In partnership with industry and communities across the nation, the NSF’s investments in engineering research and education lead to innovative technologies and sustainable impacts in health, agriculture, clean energy and water, resilient infrastructure, advanced manufacturing and communication systems, and many other areas. NSF support also builds the Nation’s workforce capacity in engineering and supports the diversity and inclusion of engineers at all career stages. Together, the NSF’s investments in engineering research and education enhance prosperity, equity and quality of life for all Americans.

    Margulies joined the NSF as the assistant director for the Directorate for Engineering in August 2021 after leading the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University. While on detail at the NSF, she is a professor and Georgia Research Alliance Eminent Scholar at Georgia Tech and Emory. She received her B.S.E. in mechanical and aerospace engineering at Princeton University, her Ph.D. in bioengineering from the University of Pennsylvania, and post-doctoral training at the Mayo Clinic. She joined the faculty at the University of Pennsylvania in 1993 as an assistant professor, rising through the ranks to professor. In 2017 she became the first faculty member tenured in both the Georgia Institute of Technology and Emory University, and she was a department chair in both the college of engineering at Georgia Tech and Emory’s school of medicine. 

    Margulies is internationally recognized for pioneering studies spanning the micro-to-macro scales and across species to identify mechanisms underlying brain injuries in children and adolescents and lung injuries associated with mechanical ventilation, leading to improved injury prevention, diagnosis and treatments. She has launched numerous training and mentorship programs for students and faculty, created institute-wide initiatives to enhance diversity and inclusion, and led innovative projects in engineering education. 

    Margulies’ transdisciplinary scholarly impact has been recognized by her election as fellow of the American Society of Mechanical Engineers, the Biomedical Engineering Society, and the American Institute for Medical and Biological Engineering, and as a member of the National Academy of Engineering and the National Academy of Medicine.  

    susan.margulies@gatech.edu

    404-385-5038

    Office Location:
    UAW 2116

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    Research Focus Areas:
  • Molecular, Cellular and Tissue Biomechanics
  • Neuroscience
  • Additional Research:
    Biomechanics of brain injury, pediatric head injury, soft tissue mechanics, ventilator-induced lung injury, lung mechanics, pathways of cellular mechanotransduction, and tissue injury thresholds.My research in head injury will continue to focus on how and why head injuries occur in adults and children and to improve detection and treatment strategies. At Georgia Tech, I will be continuing that research, looking at innovative biomarkers and new devices to detect mild traumatic brain injuries. At Emory, my research will be focused on animal models for diffuse as well as focal brain injuries—incorporating developments at Georgia Tech into our preclinical model. I also look forward to close collaborations with Children's Healthcare of Atlanta and Emory University faculty to improve the outcomes after traumatic brain injuries.

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    Hanjoong Jo

    Hanjoong Jo

    Hanjoong Jo

    John and Jan Portman Professor
    Associate Chair for Emory BME
    Coulter Department of Biomedical Engineering

    Dr. Hanjoong Jo is John and Jan Portman Professor in the Coulter Department of Biomedical Engineering (BME) at Georgia Tech and Emory University, and Professor of Medicine at Emory University. He is also the Associate Chair of Emory in BME Department. Upon graduation from Korea University, Dr. Jo received PhD under the co-mentorship of Professors John Tarbell (Chemical Engineering) and Ted Hollis (Physiology) at Pennsylvania State University in 1989. Following postdoctoral training in Jay McDonald Lab at Washington University in St. Louis and University of Alabama at Birmingham, he became Assistant Professor in Pathology and BME. Dr. Jo joined the BME Department at Georgia Tech and Emory University in 2000. He directs the Cardiovascular Mechanobiology and Nanomedicine lab. His lab studies how mechanical force associated with blood flow regulates vascular biology and cardiovascular disease, especially atherosclerosis, aortic valve (AV) calcification, and abdominal aortic aneurysms. He has published more than 150 peer-reviewed papers and edited two books. He developed the mouse model of atherosclerosis, known as partial carotid ligation model, induced by disturbed flow. His work led to the discovery of several genes (mechanosensitive genes and microRNAs) and epigenetic controlling mechanisms that are regulated by bad blood flow and play key roles in atherosclerosis and AAA. By targeting some of these mechanosensitive genes, his lab has been able to treat atherosclerosis and AAA in mice. His lab is now working on nanotechnologies to developing targeted gene and drug therapies in an effort to translate mouse studies toward clinical application. He is an elected fellow of American Institute of Medical and Biological Engineering, Biomedical Engineering Society, American Heart Association and American Physiological Society. He serves as associate editors and editorial board members of several cardiovascular and biomedical engineering journals including Scientific Reports, Circulation Research, Atherosclerosis Thrombosis Vascular Biology, Am J Physiology, Cell Molecular Bioengineering and Cardiovascular Engineering and Technology. He also has been serving as reviewers and chairs of study sections of the NIH, NSF, Veterans Administration and Am Heart Association. He also organized several international meetings, and in 2012, he served as the Chair of the Annual BME Society Meeting. He is also the founding President of Korean-American BME Society and Chairs of US-Korea Annual BMES Workshops since 2013. He has been a Distinguished Visiting Professor at Ewha Womans University and Chonbuk National University.

    hjo@bme.gatech.edu

    404-712-9654

    Office Location:
    Emory HSRB E170

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    Additional Research:
    Cardiovascular Mechanobiology and Nanomedicine LabRole of blood flow in Atherosclerosis, and Aortic valve diseaseMechanosensitive genes, MicroRNAs, and Epigenomic Regulation in Atherosclerosis and Aortic valve diseaseTherapeutics development for atherosclerosis and Aortic valve diseaseNanomedicine - In vivo RNA and drug delivery

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    James Dahlman

    James Dahlman

    James Dahlman

    Associate Professor

    James Dahlman is a bioengineer / molecular engineer whose work lies at the interface of chemistry, nanotechnology, genomics, and gene editing. His lab focuses on targeted drug delivery, in vivo gene editing, Cas9 therapies, siRNA therapies, and developing new technologies to improve biomaterial design. 

    The DahlmanLab is known for applying 'big data' technologies to nanomedicine. The lab is pioneering DNA barcoded nanoparticles; using DNA barcodes, >200 nanoparticles can be analyzed simultaneously in vivo. These nanoparticles are studied directly in vivo, and used to deliver targeted therapies like siRNA, mRNA, or Cas9. As a result of this work, James was named 1 of the 35 most innovative people under the age of 35 by MIT Technnology Review in 2018. James has won many national / international awards, and has published in Science, Nature Nanotechnology, Nature Biotechnology, Nature Cell Biology, Cell, Science Translational Medicine, PNAS, JACS, ACS Nano, Nano Letters, and other journals. James has also designed nanoparticles that efficiently deliver RNAs to the lung and heart. These nanoparticles can deliver 5 siRNAs at once in vivo, and are under consideration for clinical development. As a result, the lab has an interest in immunology and vascular biology. 

    James supports entirely new research students come up with independently. To this end, DahlmanLab students learn how to (i) generate new ideas, (ii) select the good ones, and (iii) efficiently test whether the good ideas will actually work. 

    Dahlman Lab students learn how to design/characterize/administer nanoparticles, how to isolate different cell types in vivo, how to rationally design DNA to record information, Cas9 therapies, and deep sequencing. As a result, the lab is an interdisciplinary group with students that have backgrounds in medicinal chemistry, BME, bioinformatics, biochemistry, and other fields. The lab welcomes students with all types of scientific backgrounds. The lab firmly stands by students, independent of their personal beliefs, preferences, or backgrounds.

    james.dahlman@bme.gatech.edu

    404-385-5262

    Office Location:
    UAW 2101

    Website

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    Research Focus Areas:
  • Biomaterials
  • Cancer Biology
  • Drug Design, Development and Delivery
  • Regenerative Medicine
  • Systems Biology
  • Additional Research:
    In the Dahlman Lab, we focus on the interface between nanotechology, molecular biology, and genomics. We design drug delivery vehicles that target RNA and other nucleic acids to cells in the body. We have delivered RNAs to endothelial cells, and have treated heart disease, cancer, inflammation, pulmonary hypertension, emphysema, and even vein graft disease. Because we can deliver RNAs to blood vessels at low doses, sometimes we decide to deliver multiple therapeutic RNAs to the same cell at once. These 'multigene therapies' have been used to treat heart disease and cancer. Why is this important? Most diseases are caused by combinations of genes, not a single gene. We also rationally design the nucleic acids we want to deliver. For example, we re-engineered the Cas9 sgRNA to turn on genes, instead of turning them off. This enabled us to easily turn on gene A and turn off gene B in the same cell.

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    Gabe Kwong

    Gabe Kwong

    Gabe Kwong

    Associate Professor
    Director, Laboratory for Synthetic Immunity

    Dr. Gabe Kwong is an Assistant Professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Tech School of Engineering and Emory School of Medicine. His research program is conducted at the interface of the life sciences, medicine and engineering where a central focus is understanding how to harness the sophisticated defense mechanisms of immune cells to eradicate disease and provide protective immunity. Kwong has pioneered numerous biomedical technologies and published in leading scientific journals such as Nature Biotechnology and Nature Medicine. His work has been profiled broadly including coverage in The Economist, NPR, BBC, and WGBH-2, Boston 's PBS station. Professor Kwong earned his B.S. in Bioengineering with Highest Honors from the University of California, Berkeley and his Ph.D. in Bioengineering from California Institute of Technology with Professor James R. Heath. He conducted postdoctoral studies at Massachusetts Institute of Technology with Professor Sangeeta N. Bhatia. For his work, Dr. Kwong has been awarded the NIH Ruth L. Kirschstein National Research Service Award, named a "Future Leader in Cancer Research and Translational Medicine" by the Massachusetts General Hospital, and awarded the Burroughs Wellcome Fund Career Award at the Scientific Interface, a distinction given to the 10 most innovative bioengineers in the nation. Dr. Kwong holds seven issued or pending patents in cancer nanotechnology.

    gkwong@gatech.edu

    404-385-3746

    Office Location:
    Marcus Nanotechnology 3132

    Website

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    Research Focus Areas:
  • Biomaterials
  • Cancer Biology
  • Cell Manufacturing
  • Chemical Biology
  • Drug Design, Development and Delivery
  • Miniaturization & Integration
  • Nanomaterials
  • Systems Biology
  • Additional Research:
    Human health has been transformed by our collective capacity to engineer immunity — from the pivotal development of the smallpox vaccine to the curative potential of recent cancer immunotherapies. These examples motivate our research program that is conducted at the interface of Engineering and Immunology, and where we develop biomedical technologies and applications that shape a diverse array of immunological systems.The questions that are central to our exploration include: How do we begin to study an individual's repertoire of well over one billion immune cells when current technologies only allow us to study a handful of cells at a time? What are the biomarkers of immunological health as the body responds to disease and ageing, and how may these indicators trigger clinical decisions? And how can we genetically rewire immune cells to provide them with entirely new functions to better fight complex diseases such as cancer?To aid in our studies, we use high-throughput technologies such as next-generation sequencing and quantitative mass spectrometry, and pioneer the development of micro- and nanotechnologies in order to achieve our goals. We focus on clinical problems in cancer, infectious diseases and autoimmunity, and ultimately strive to translate key findings into therapies for patients.

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    Michelle LaPlaca

    Michelle LaPlaca

    Michelle LaPlaca

    Professor

    Michelle C. LaPlaca, Ph.D. is an Associate Professor in the Department of Biomedical Engineering, a joint department between Georgia Tech and Emory University. Dr. LaPlaca earned her undergraduate degree in Biomedical Engineering from The Catholic University of America, Washington, DC, in 1991 and her M.S.E. (1992) and Ph.D. (1996) in Bioengineering from the University of Pennsylvania, Philadelphia, PA, in the area of neuronal injury biomechanics. Following post-doctoral training in Neurosurgery at the University of Pennsylvania’s Head Injury Center from 1996-98, she joined the faculty at Georgia Tech. Dr. LaPlaca’s research interests are in neurotrauma, specifically: traumatic brain injury, injury biomechanics, cell culture modeling of traumatic injury, neural tissue engineering, and cognitive impairment associated with brain injury and aging. Her research is funded by NIH, NSF, and the Coulter Foundation.

    michelle.laplaca@bme.gatech.edu

    404-385-0629

    Office Location:
    UAW 3109

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    Research Focus Areas:
  • Biomaterials
  • Molecular, Cellular and Tissue Biomechanics
  • Neuroscience
  • Regenerative Medicine
  • Additional Research:
    LaPlaca's broad research interests are in neurotrauma, injury biomechanics, and neuroengineering as they relate to traumatic brain injury (TBI). The goals are to better understand acute injury mechanisms in order to develop strategies for neuroprotection, neural repair, and more sensitive diagnostics. More specifically, the lab studies mechanotransduction mechanisms, cellular tolerances to traumatic loading, and plasma membrane damage, including mechanoporation and inflammatory- & free radical-induced damage. We are coupling these mechanistic-based studies with –omics discovery in order to identify new biomarker candidates. In addition, LaPlaca and colleagues have developed and patented an abbreviated, objective clinical neuropsychological tool (Display Enhanced Testing for Cognitive Impairment and Traumatic Brain Injury, DETECT) to assess cognitive impairment associated with concussion and mild cognitive impairment. An immersive environment, coupled with an objective scoring algorithm, make this tool attractive for sideline assessment of concussion in athletic settings. Through working on both basic and clinical levels she is applying systems engineering approaches to elucidate the complexity of TBI and promoting bidirectional lab-to-clinical translation.

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    Shella Keilholz

    Shella Keilholz

    Shella Keilholz

    Associate Professor

    Dr. Keilholz has been working in preclinical imaging for more than twenty years, with the goal of using animal models to improve the analysis of human MRI imaging. Her research uses multimodal approaches to extract information about neural dynamics from functional neuroimaging studies.

    sk233@mail.gatech.edu

    404-727-2433

    Office Location:
    Emory, HSRB W230

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    Research Focus Areas:
  • Neuroscience
  • Additional Research:
    The goal of my research is to develop a method for mapping spontaneous activity throughout the whole brain with high spatial and temporal resolution, with the intention of using this technique to characterize alterations in dynamic neural activity linked to dysfunction and to identify potential targets for intervention. My primary expertise is in fMRI and functional connectivity mapping, and since my lab was established at Emory, we have focused on obtaining information about the dynamic activity of functional networks from the BOLD signal. Despite BOLD's indirect relationship to neural signals, evidence is growing that the BOLD fluctuations provide information about behaviorally relevant network activity. We take a two-pronged approach to the problem, combining MRI with direct neural measures like electrophysiology and optical imaging in the rodent, or with EEG and behavioral outputs in the human. Our effort to understand the relationship between BOLD and electrical or optical recordings (very different signals that cover very different spatial and temporal scales) has led us to develop new approaches to data analysis that include spectral, spatial, and temporal information. To better understand the large-scale dynamics of brain activity, we have become fluent in network modeling, nonlinear dynamics, and machine learning.

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    Felipe Garcia Quiroz

    Felipe Garcia Quiroz

    Felipe Quiroz

    Assistant Professor

    Felipe trained as a biomedical engineer in his native Colombia before obtaining a PhD from the Biomedical Engineering department of Duke University. At Duke, working in the laboratory of Ashutosh Chilkoti, he focused on the engineering of genetically-encoded, self-assembling protein polymers. An important outcome of this PhD work was the elucidation of sequence rules to program the phase separation behavior of intrinsically disordered proteins (IDPs). Motivated by a newly acquired ability to engineer the phase behavior of IDPs, for his postdoctoral work he turned to their poorly-understood biology. To pursue skin as an outstanding biological system, Felipe joined the group of Elaine Fuchs at Rockefeller University. Felipe’s postdoctoral research led to the discovery that liquid-liquid phase separation drives the process of skin barrier formation. In 2020, he established the Quiroz Lab in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, where he is currently an Assistant Professor. Felipe is the recipient of multiple research awards, including a Career Award at the Scientific Interface from the Burroughs Wellcome Fund and the NIH Director’s New Innovator Award.


    404-251-5435

    Office Location:
    Health Sciences Research Building, Room E184 (Emory)

    Website

  • Coulter Department of Biomedical Engineering
  • Coulter Department of Biomedical Engineering
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    Research Focus Areas:
  • Biomaterials
  • Drug Design, Development and Delivery
  • Molecular, Cellular and Tissue Biomechanics
  • Regenerative Medicine
  • Systems Biology

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    Melissa Kemp

    Melissa Kemp

    Melissa Kemp

    Professor
    Georgia Cancer Coalition Distinguished Cancer Scholar

    Melissa Lambeth Kemp received her B.S. in Nuclear Engineering from MIT and her Ph.D. in Bioengineering from University of Washington. Dr. Kemp joined the faculty at Georgia Tech in 2006 after completing postdoctoral training at MIT. Her expertise is in computational modeling of metabolism and signal transduction, as well as developing statistical modeling tools to examine network relationships in high-dimension datasets. One major aspect of her research program linking ROS – the byproducts of aerobic metabolism – to the fundamental way that cells interpret instructions from their environment, their neighbors, and their own genetic blueprint. Specific applications of her diverse work include systems modeling of transient phosphatase oxidation of kinase cascades, patient-specific differences in cytotoxicity to redox-cycled chemotherapeutics and radiation, and the coordination of oxidative metabolism with epithelial-to-mesenchymal transition. Her research program also includes a component of developing high-throughput screening methods for assaying cue-signal-response relationships in cells and analytical tools for single cell gene expression. 

    Dr. Kemp currently serves as the Research Director of the multi-site NSF Engineering Research Center “Cell Manufacturing Technologies”. In her former role as Associate Director of the NSF Science and Technology Center “Emergent Behavior of Integrated Cellular Systems”, she spearheaded the multi-site center’s computational activities by developing agent-based models of context-dependent cellular decisions to generate new hypotheses of intercellular communication in pluripotent stem cell differentiation and emergent patterning; this work continues currently in quantifying organizational principles and spatial relationships in iPSC-derived tissues from multi-omics data. Dr. Kemp’s career honors include a Whitaker Graduate Fellowship, Merck/CSBi postdoctoral fellowship, Georgia Cancer Coalition Distinguished Scholar, NIH New Innovator Award, and the CSB2 Prize for Innovative Measurement Methods from the Council for Systems Biology in Boston.

    melissa.kemp@bme.gatech.edu

    404-385-6341

    Office Location:
    EBB 3019

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    Research Focus Areas:
  • Cancer Biology
  • Chemical Biology
  • Systems Biology
  • Additional Research:
    Systems biology, computational modeling, redox metabolism and signal tranduction.The Kemp Lab is focused on understanding how metabolism influences the decisions that cells make. Aging, stem cell differentiation, cancer metastasis, and inflammation rely on progressive changes in metabolism resulting in increased levels of reactive oxygen species. Collectively, the accumulation of these molecules is known as cellular oxidation, and pathological levels are referred to as oxidative stress. Our lab develops systems biology tools for investigating how cellular oxidation influences cellular fate and interpretation of cues from the extracellular environment. We are interested in the collective behavior that arises during stem cell differentiation, immune cell responses, or drug treatments from metabolic diversity in individual cells. Because of the numerous biochemical reactions involved, we develop computational models and analytical approaches to understand how complex protein network properties are influenced by redox-sensitive proteins; these proteins typically have reactive thiol groups that are post-translationally regulated in the presence of reactive oxygen species to alter activity and/or function. Experimentally, we develop novel high-throughput single cell techniques for the detection and quantification of intracellular oxidation.

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